ALDH enzyme marks melanoma stem cells Malignancy stem cells are defined by three skills: differentiation, self-renewal and their ability to seed a tumor More information here . These stem cells resist chemotherapy and many researchers posit their part in relapse. A University of Colorado Cancer Middle study published in the journal Stem Cells recently, shows that melanoma cells with these skills are marked by the enzyme ALDH, and imagines brand-new therapies to target high-ALDH cells, potentially weeding your body of these most dangerous cancers creators. ‘We’ve noticed ALDH as a stem cell marker in additional cancer types, however, not in melanoma, and until now its function provides been largely unknown,’ says the paper’s senior author, Mayumi Fujita, MD, PhD, investigator at the CU Cancer Center and associate professor in the Section of Dermatology at the CU School of Medicine.