All 1234 individuals were included in the efficacy analysis; 98 were lost to follow-up. For the toxicity analysis, 873 patients were evaluated at 5 years and 455 patients were evaluated at 10 years. Local Recurrence Regional invasive recurrence of breast cancer was the first event in 83 patients . The cumulative incidence of regional recurrence was comparable in the two groups . At a decade, the cumulative incidence of local recurrence was 6.7 percent in the control group in comparison with 6.2 percent in the hypofractionated-radiation group ; that’s, we’ve 97.5 percent self-confidence that the hypofractionated program is no worse compared to the control program by 2.5 %age points.Gahl, M.D., Ph.D., Richard Warth, M.D., Ph.D., Eamonn Sheridan, M.D., and Robert Kleta, M.D., Ph.D.: Epilepsy, Ataxia, Sensorineural Deafness, Tubulopathy, and KCNJ10 Mutations The analysis of molecular defects in rare inherited renal tubular diseases has substantially advanced both our knowledge of renal salt and water handling and the management of common disorders such as for example systemic hypertension.1-7 Two well-known disorders of renal tubular salt handling, Bartter’s syndrome and the Gitelman syndrome, are characterized by polyuria and normotensive hypokalemic metabolic alkalosis.