Hunting down a dangerous pathwaybreast cancer stem cells from other primary cancer cells by the presence of the surface protein CD44 and CD24 low or be sorted absent in tumor cells.found the high expression high expression of EZH2 in breast cancer stem cells reduced the levels of the tumor suppressor RAD1 and correlated with high-grade tumors in a sample of 168 human breast cancer tumors, it also increased the number of tumor. Initiating cells in culture.
He is also with the Center for Molecular Medicine and Graduate Institute of Cancer Biology, both of the China Medical University Hospital, Taichung, Taiwan, and Asia University in Taichung attached.
EZH2 blocks DNA damage repairThe molecular chain of events that to renew itself, the survival and growth of these breast cancer stem cells improves by oxygen-poor regions of a tumor may be initiated, Hung said. This hypoxia stimulates a protein that in turn causes over-expression of EZH2.Constantly be using in order to determine whether the program be on track, preliminary results through assessment, accelerate causally linked to the outcome from interest in. Was has needs a ‘toolkit ‘of approaches for compelling evidence of cause and effect relationships, no the large investment out of time, money and manpower formally formal randomized designed developed. Implementation of Sciences context be contribute to ensuring that programs to the intended results of through ‘strategic use of real-time data collection, the program in progress possible corrections ‘, Padian and colleagues write. ‘Applying an IS framework of PEPFAR Programmes sharpening our ability help partner countries in the selection strategic programs the greatest benefits the most value to most efficient methods.
In fact, that collection and exchange out of information about HIV / AIDS program implementation with the global community a vital part the next phase of the PEPFAR will be. Acceleration this work are allow PEPFAR support for the strategic assistance and concentrate where it be are the greatest impact, while enhancing the implementation of the efficiency and sustainability of, the authors conclude.