The secondary basic safety outcome was the composite of main bleeding and clinically relevant nonmajor bleeding. Bleeding was thought as major if it had been overt and associated with a decrease in the hemoglobin level of 2 g per deciliter or more, needed the transfusion of 2 or more units of blood, occurred into a essential site, or contributed to loss of life.6 Clinically relevant nonmajor bleeding was defined as overt bleeding not meeting the requirements for main bleeding but connected with medical intervention, connection with a physician, interruption of the scholarly study drug, or impairment or distress in carrying out activities of daily life.Grobman, M.D., M.B.A., Susan Klugman, M.D., Thomas Scholl, Ph.D., Joe Leigh Simpson, M.D., Kimberly McCall, B.S., Vimla S. Aggarwal, M.B., B.S., Brian Bunke, B.S., Odelia Nahum, M.Sc., Ankita Patel, Ph.D., Allen N. Lamb, Ph.D., Elizabeth A. Thom, Ph.D., Arthur L. Beaudet, M.D., David H. Ledbetter, Ph.D., Lisa G. Shaffer, Ph.D., and Laird Jackson, M.D.: Chromosomal Microarray versus Karyotyping for Prenatal Diagnosis The development of array-based molecular cytogenetic techniques has improved the detection of small genomic deletions and duplications that are not routinely seen on karyotyping, the typical cytogenetic analysis performed. Copy-number variants result in a variation from the expected amount of copies of a segment of DNA . Copy-number variants could be either pathogenic or benign, depending on their location and genetic articles.