The first U.S. Affected individual was enrolled into the EXCEL trial at Turkey Creek Medical Center in Knoxville, Tenn., by Michael L. Maggart, M.D., cardiothoracic doctor, and Malcolm T. Foster, M.D., interventional cardiologist. Left primary disease is usually a high-risk subset of coronary artery disease including blockage of the still left primary coronary artery, which branches off the aorta to provide blood flow to the left ventricle of the heart. Surgery traditionally has been the standard treatment for left primary disease, with coronary stenting reserved only for patients at high risk for medical procedures who are protected by a previous bypass graft to at least one of the two major coronary arteries that branch off the still left primary artery.PMID: 15505459 Evaluation of efficacy of the perioperative administration of venlafaxine XR in the prevention of postmastectomy pain syndrome. Reuben SS, Makari-Judson G, Lurie SD. J Pain Sign Manage. 2004 Feb;27:133-9. PMID: 15157037 Analgesic aftereffect of clonidine added to bupivacaine 0.125 percent in paediatric caudal blockade. Joshi W, Connelly NR, Freeman K, Reuben SS. Paediatr Anaesth. 2004 Jun;14:483-6. PMID: 15153211 The perioperative usage of cyclooxygenase-2 selective nonsteroidal antiinflammatory drugs may provide a safer alternative. Reuben SS, Connelly NR. Anesthesiology. 2004 Mar;100:748. No abstract available. PMID: 15109000 An evaluation of the security and efficacy of administering rofecoxib for postoperative discomfort management.